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doi:10.22028/D291-46689 | Title: | Clinical Outcomes of Minced Cartilage Treatment (AutoCart™) for Medial Osteochondral Lesions of the Talus: A Prospective One-Year Follow-Up Study |
| Author(s): | Roth, Klaus E. Salzmann, Gian M. Winter, Philipp Schmidtmann, Irene Maier, Gerrit Cochrane, Isabelle Ossendorff, Robert Klos, Kajetan Drees, Philipp |
| Language: | English |
| Title: | Journal of Clinical Medicine |
| Volume: | 14 |
| Issue: | 24 |
| Publisher/Platform: | MDPI |
| Year of Publication: | 2025 |
| Free key words: | minced cartilage implantation cartilage regeneration talus ankle |
| DDC notations: | 610 Medicine and health |
| Publikation type: | Journal Article |
| Abstract: | Background/Objectives: This prospective study aims to assess the clinical outcomes of the AutoCart™ technique for the treatment of medial osteochondral lesions of the talus (OLT). Methods: 29 consecutive patients treated for medial OLT were included. Demographic char acteristics and preoperative imaging (MRI and CT) were reviewed, and patient-reported outcome measures (PROMs)—including a Visual Analog Pain Scale (VAS), Foot Function In dex (FFI), Foot and Ankle Ability Measure (FAAM), and the Veterans RAND 12-Item Health Survey (VR-12)—were assessed preoperatively and at 6 and 12 months post-treatment. Results: In the cohort, 14 (48%) were female, 13 (45%) were male, and 2 (7%) did not disclose their gender. Median age was 35.5 years (interquartile range: 23.0–49.5). Mean defect size was 121.95 ± 84.46 mm2 . Three patients were treated entirely arthroscopically, while 26 patients underwent medial malleolar osteotomy with cancellous bone grafting from the calcaneus for cartilage fragment placement. At one-year follow-up, there were significant improvements in pain and functional outcomes. The VAS score showed a mean reduction of 1.3 points (95% CI: −2.6 to −0.1; p = 0.036). Strong improvement was observed in the FFI, with a mean reduction of 13.3 points (95% CI: −21.0 to −5.6; p = 0.001). The FAAM Sports subscale showed a significant increase of 18.6 points (95% CI: 7.0 to 30.1; p = 0.002). Conclusions: Patients demonstrate clinical improvement after minced cartilage implantation with the AutoCart™ technique. These findings suggest that the minced cartilage procedure is a viable treatment option for medial OLTs, though further studies are needed to assess long-term efficacy. |
| DOI of the first publication: | 10.3390/jcm14248710 |
| URL of the first publication: | https://doi.org/10.3390/jcm14248710 |
| Link to this record: | urn:nbn:de:bsz:291--ds-466890 hdl:20.500.11880/40929 http://dx.doi.org/10.22028/D291-46689 |
| ISSN: | 2077-0383 |
| Date of registration: | 5-Jan-2026 |
| Description of the related object: | Supplementary Materials |
| Related object: | https://www.mdpi.com/article/10.3390/jcm14248710/s1 |
| Faculty: | M - Medizinische Fakultät |
| Department: | M - Orthopädie |
| Professorship: | M - Prof. Dr. Stefan Landgraeber |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
| File | Description | Size | Format | |
|---|---|---|---|---|
| jcm-14-08710.pdf | 3,01 MB | Adobe PDF | View/Open |
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