Please use this identifier to cite or link to this item: doi:10.22028/D291-46689
Title: Clinical Outcomes of Minced Cartilage Treatment (AutoCart™) for Medial Osteochondral Lesions of the Talus: A Prospective One-Year Follow-Up Study
Author(s): Roth, Klaus E.
Salzmann, Gian M.
Winter, Philipp
Schmidtmann, Irene
Maier, Gerrit
Cochrane, Isabelle
Ossendorff, Robert
Klos, Kajetan
Drees, Philipp
Language: English
Title: Journal of Clinical Medicine
Volume: 14
Issue: 24
Publisher/Platform: MDPI
Year of Publication: 2025
Free key words: minced cartilage implantation
cartilage regeneration
talus
ankle
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background/Objectives: This prospective study aims to assess the clinical outcomes of the AutoCart™ technique for the treatment of medial osteochondral lesions of the talus (OLT). Methods: 29 consecutive patients treated for medial OLT were included. Demographic char acteristics and preoperative imaging (MRI and CT) were reviewed, and patient-reported outcome measures (PROMs)—including a Visual Analog Pain Scale (VAS), Foot Function In dex (FFI), Foot and Ankle Ability Measure (FAAM), and the Veterans RAND 12-Item Health Survey (VR-12)—were assessed preoperatively and at 6 and 12 months post-treatment. Results: In the cohort, 14 (48%) were female, 13 (45%) were male, and 2 (7%) did not disclose their gender. Median age was 35.5 years (interquartile range: 23.0–49.5). Mean defect size was 121.95 ± 84.46 mm2 . Three patients were treated entirely arthroscopically, while 26 patients underwent medial malleolar osteotomy with cancellous bone grafting from the calcaneus for cartilage fragment placement. At one-year follow-up, there were significant improvements in pain and functional outcomes. The VAS score showed a mean reduction of 1.3 points (95% CI: −2.6 to −0.1; p = 0.036). Strong improvement was observed in the FFI, with a mean reduction of 13.3 points (95% CI: −21.0 to −5.6; p = 0.001). The FAAM Sports subscale showed a significant increase of 18.6 points (95% CI: 7.0 to 30.1; p = 0.002). Conclusions: Patients demonstrate clinical improvement after minced cartilage implantation with the AutoCart™ technique. These findings suggest that the minced cartilage procedure is a viable treatment option for medial OLTs, though further studies are needed to assess long-term efficacy.
DOI of the first publication: 10.3390/jcm14248710
URL of the first publication: https://doi.org/10.3390/jcm14248710
Link to this record: urn:nbn:de:bsz:291--ds-466890
hdl:20.500.11880/40929
http://dx.doi.org/10.22028/D291-46689
ISSN: 2077-0383
Date of registration: 5-Jan-2026
Description of the related object: Supplementary Materials
Related object: https://www.mdpi.com/article/10.3390/jcm14248710/s1
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Stefan Landgraeber
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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