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doi:10.22028/D291-43576
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Title: | Skin Markers of Premature Ageing in Patients with COPD: Results Form COSYCONET |
Author(s): | Melzer, Thomas Graf, Veronika Kronseder, Angelika Karrasch, Stefan Kerschner, Martina Vogelmeier, Claus F. Bals, Robert ![]() Alter, Peter Watz, Henrik Fähndrich, Sebastian Behr, Jürgen Waschki, Benjamin Trudzinski, Franziska Christina Jörres, Rudolf A. Kahnert, Kathrin |
Language: | English |
In: | |
Title: | Journal of Clinical Medicine |
Volume: | 13 |
Issue: | 22 |
Publisher/Platform: | MDPI |
Year of Publication: | 2024 |
Free key words: | age-related diseases exposome COPD emphysema skin wrinkles |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background: Chronic obstructive pulmonary disease (COPD) is commonly associated with ageing, with the prevalence and severity increasing by age. Smoking-induced premature ageing is thought to contribute to COPD, particularly lung emphysema. This study aimed to explore the relationship between lung function impairment and skin texture, as a marker of biological or premature ageing, in COPD patients. Methods: A subcohort from the COSYCONET COPD-study was analyzed, where skin-relief replicas of the eye’s outer corner and mid-lower inner arm were collected, along with semi-quantitative facial photographs. We examined the correlation between skin parameters and lung function, particularly the diffusing capacity (TLCO) as an indicator of emphysema. Results: Among 46 COPD patients (69 ± 8 years, 52% female), skin texture from the inner forearm, but not from the eye corner, was significantly associated with TLCO% predicted, with a higher skin roughness correlating with a lower TLCO (p = 0.015). This relationship persisted after adjusting for age, BMI, sex, pack years, and smoking status. No significant associations were found with facial photographs. Conclusions: These findings suggest that systemic ageing, reflected in inner arm skin texture, is linked to lung emphysema. Skin ageing markers may be valuable in future interventional studies involving anti-ageing treatments. |
DOI of the first publication: | 10.3390/jcm13226972 |
URL of the first publication: | https://doi.org/10.3390/jcm13226972 |
Link to this record: | urn:nbn:de:bsz:291--ds-435760 hdl:20.500.11880/39047 http://dx.doi.org/10.22028/D291-43576 |
ISSN: | 2077-0383 |
Date of registration: | 27-Nov-2024 |
Description of the related object: | Supplementary Materials |
Related object: | https://www.mdpi.com/article/10.3390/jcm13226972/s1 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Prof. Dr. Robert Bals |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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