Please use this identifier to cite or link to this item:
doi:10.22028/D291-38532
Title: | Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery |
Author(s): | Weinzierl, Andrea Ampofo, Emmanuel Menger, Michael D. Laschke, Matthias W. |
Language: | English |
Title: | Frontiers in Pharmacology |
Volume: | 13 |
Publisher/Platform: | Frontiers |
Year of Publication: | 2022 |
Free key words: | phytochemicals nutraceuticals herbal medicine flap necrosis ischemia–reperfusion injury |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms. |
DOI of the first publication: | 10.3389/fphar.2022.864351 |
URL of the first publication: | https://www.frontiersin.org/articles/10.3389/fphar.2022.864351 |
Link to this record: | urn:nbn:de:bsz:291--ds-385320 hdl:20.500.11880/34737 http://dx.doi.org/10.22028/D291-38532 |
ISSN: | 1663-9812 |
Date of registration: | 12-Dec-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Chirurgie |
Professorship: | M - Prof. Dr. Michael D. Menger |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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File | Description | Size | Format | |
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fphar-13-864351.pdf | 1,4 MB | Adobe PDF | View/Open |
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