Please use this identifier to cite or link to this item: doi:10.22028/D291-38532
Title: Tissue-Protective Mechanisms of Bioactive Phytochemicals in Flap Surgery
Author(s): Weinzierl, Andrea
Ampofo, Emmanuel
Menger, Michael D.
Laschke, Matthias W.
Language: English
Title: Frontiers in Pharmacology
Volume: 13
Publisher/Platform: Frontiers
Year of Publication: 2022
Free key words: phytochemicals
nutraceuticals
herbal medicine
flap
necrosis
ischemia–reperfusion injury
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Despite careful preoperative planning, surgical flaps are prone to ischemic tissue damage and ischemia–reperfusion injury. The resulting wound breakdown and flap necrosis increase both treatment costs and patient morbidity. Hence, there is a need for strategies to promote flap survival and prevent ischemia-induced tissue damage. Phytochemicals, defined as non-essential, bioactive, and plant-derived molecules, are attractive candidates for perioperative treatment as they have little to no side effects and are well tolerated by most patients. Furthermore, they have been shown to exert beneficial combinations of pro-angiogenic, anti-inflammatory, anti-oxidant, and anti-apoptotic effects. This review provides an overview of bioactive phytochemicals that have been used to increase flap survival in preclinical animal models and discusses the underlying molecular and cellular mechanisms.
DOI of the first publication: 10.3389/fphar.2022.864351
URL of the first publication: https://www.frontiersin.org/articles/10.3389/fphar.2022.864351
Link to this record: urn:nbn:de:bsz:291--ds-385320
hdl:20.500.11880/34737
http://dx.doi.org/10.22028/D291-38532
ISSN: 1663-9812
Date of registration: 12-Dec-2022
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
Professorship: M - Prof. Dr. Michael D. Menger
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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