Please use this identifier to cite or link to this item:
doi:10.22028/D291-34762
Title: | IL-17C and IL-17RE Promote Wound Closure in a Staphylococcus aureus-Based Murine Wound Infection Model |
Author(s): | Pätzold, Linda Stark, Alexandra Ritzmann, Felix Meier, Carola Tschernig, Thomas Reichrath, Jörg Bals, Robert Bischoff, Markus Beisswenger, Christoph |
Language: | English |
Title: | Microorganisms |
Volume: | 9 |
Issue: | 9 |
Publisher/Platform: | MDPI |
Year of Publication: | 2021 |
Free key words: | Staphylococcus aureus wound infection interleukin-17C wound closure |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | The epithelial cytokine interleukin-17C (IL-17C) mediates inflammation through the interleukin 17 receptor E (IL-17RE). Prior studies showed a detrimental role of IL-17C in the pathogenesis of immune-mediated skin diseases (e.g., psoriasis). Here, we examined the role of IL-17C/IL-17RE in wound closure in a Staphylococcus aureus wound infection model. We demonstrate that wound closure is significantly delayed in IL-17RE (Il-17re−/−)- and 17C (Il-17c−/−)-deficient mice. There was no significant difference between WT, Il-17re−/−, and Il-17c−/− mice in the absence of infection. Deficiency for IL-17RE and IL-17C did not significantly affect the elimination of bacteria. IL-17C expression was increased in the epidermis of human S. aureus-infected skin. Our results indicate that the IL-17C/IL-17RE axis contributes to the closure of infected wounds but does not contribute to the elimination of S. aureus. |
DOI of the first publication: | 10.3390/microorganisms9091821 |
Link to this record: | urn:nbn:de:bsz:291--ds-347628 hdl:20.500.11880/31801 http://dx.doi.org/10.22028/D291-34762 |
ISSN: | 2076-2607 |
Date of registration: | 27-Sep-2021 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Anatomie und Zellbiologie M - Dermatologie M - Infektionsmedizin M - Innere Medizin |
Professorship: | M - Prof. Dr. Robert Bals M - Prof. Dr. Dr. Sören Becker M - Prof. Dr. Carola Meier M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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microorganisms-09-01821.pdf | 2,6 MB | Adobe PDF | View/Open |
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