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Titel: Discovery and Heterologous Production of New Cyclic Depsibosamycins
VerfasserIn: Stierhof, Marc
Myronovskyi, Maksym
Zapp, Josef
Luzhetskyy, Andriy
Sprache: Englisch
Titel: Microorganisms
Bandnummer: 9
Heft: 7
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: bosamycin
Streptomyces
heterologous expression
NRPS
cyclic peptide
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Streptomyces are producers of valuable secondary metabolites with unique scaffolds that perform a plethora of biological functions. Nonribosomal peptides are of special interest due to their variety and complexity. They are synthesized by nonribosomal peptide synthetases, large biosynthetic machineries that are encoded in the genome of many Streptomyces species. The identification of new peptides and the corresponding biosynthetic gene clusters is of major interest since knowledge can be used to facilitate combinatorial biosynthesis and chemical semisynthesis of natural products. The recently discovered bosamycins are linear octapeptides with an interesting 5-OMe tyrosine moiety and various modifications at the N-terminus. In this study, the new cyclic depsibosamycins B, C, and D from Streptomyces aurantiacus LU19075 were discovered. In comparison to the linear bosamycins B, C, and D, which were also produced by the strain, the cyclic depsibosamycins showed a side-chain-to-tail lactonization of serine and glycine, leading to a ring of four amino acids. In silico identification and heterologous expression of the depsibosamycin (dbm) gene cluster indicated that the cyclic peptides, rather than the linear derivatives, are the main products of the cluster.
DOI der Erstveröffentlichung: 10.3390/microorganisms9071396
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-344560
hdl:20.500.11880/31605
http://dx.doi.org/10.22028/D291-34456
ISSN: 2076-2607
Datum des Eintrags: 3-Aug-2021
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/microorganisms9071396/s1
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Alexandra K. Kiemer
NT - Prof. Dr. Andriy Luzhetskyy
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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