Please use this identifier to cite or link to this item: doi:10.22028/D291-34266
Title: The medium-chain fatty acid decanoic acid reduces oxidative stress levels in neuroblastoma cells
Author(s): Mett, Janine
Müller, Uli
Language: English
Title: Scientific Reports
Volume: 11
Issue: 1
Publisher/Platform: Springer Nature
Year of Publication: 2021
Free key words: Cell biology
Neuroscience
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Enhanced oxidative stress is a contributing factor in the pathogenesis of several neurodegenerative disorders such as Alzheimer´s disease. Beneficial effects have been demonstrated for medium-chain fatty acids (MCFAs) nutritionally administered as medium-chain triglycerides (MCTs) or coconut oil (CO). The observed effects on cognitive impairment are generally attributed to the hepatic metabolism of MCFAs, where resulting ketone bodies serve as an alternate energy source to compensate for the impaired glucose utilisation in the human brain. Here we show that the saturated MCFA decanoic acid (10:0) reduces the oxidative stress level in two different neuroblastoma cell lines. Phosphatidylcholine (PC) containing decanoic acid (10:0) (PC10:0/10:0) reduced the cellular H2O2 release in comparison to solvent, L-α-Glycerophosphorylcholine and PC containing the long-chain fatty acid (LCFA) arachidic acid (20:0). This effect seems to be at least partially based on an upregulation of catalase activity, independent of alterations in catalase gene expression. Further, PC10:0/10:0 decreased the intracellular oxidative stress level and attenuated the H2O2-induced cell death. It did not affect the level of the ketone body β-hydroxybutyrate (βHB). These results indicate that decanoic acid (10:0) and possibly MCFAs in general directly reduce oxidative stress levels independent of ketone levels and thus may promote neuronal health.
DOI of the first publication: 10.1038/s41598-021-85523-9
Link to this record: urn:nbn:de:bsz:291--ds-342663
hdl:20.500.11880/31436
http://dx.doi.org/10.22028/D291-34266
ISSN: 2045-2322
Date of registration: 25-Jun-2021
Description of the related object: Supplementary Information
Related object: https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-021-85523-9/MediaObjects/41598_2021_85523_MOESM1_ESM.pdf
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Uli Müller
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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