Please use this identifier to cite or link to this item: doi:10.22028/D291-33577
Title: IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations
Author(s): Vella, Giovanna
Ritzmann, Felix
Wolf, Lisa
Kamyschnikov, Andreas
Stodden, Hannah
Herr, Christian
Slevogt, Hortense
Bals, Robert
Beißwenger, Christoph
Language: English
Title: PLOS ONE
Volume: 16
Issue: 1
Publisher/Platform: Public Library of Science
Year of Publication: 2021
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Neutrophilic inflammation results in loss of lung function in chronic obstructive pulmonary disease (COPD). Gram-negative bacteria, such as nontypeable Haemophilus influenzae (NTHi), trigger acute exacerbations of COPD (AECOPD) and contribute to chronic lung inflammation. The pro-inflammatory cytokine interleukin-17C (IL-17C) is expressed by airway epithelial cells and regulates neutrophilic chemotaxis. Here, we explored the function of IL-17C in NTHi- and cigarette smoke (CS)-induced models of COPD. Neutrophilic inflammation and tissue destruction were decreased in lungs of IL-17C-deficient mice (Il-17c-/-) chronically exposed to NTHi. Numbers of pulmonary neutrophils were decreased in Il-17c-/- mice after acute exposure to the combination of NTHi and CS. However, Il-17c-/- mice were not protected from CS-induced lung inflammation. In a preliminary patient study, we show that IL-17C is present in sputum samples obtained during AECOPD and associates with disease severity. Concentrations of IL-17C were significantly increased during advanced COPD (GOLD III/IV) compared to moderate COPD (GOLD I/II). Concentrations of IL-17A and IL-17E did not associate with disease severity. Our data suggest that IL-17C promotes harmful pulmonary inflammation triggered by bacteria in COPD.
DOI of the first publication: 10.1371/journal.pone.0243484
Link to this record: urn:nbn:de:bsz:291--ds-335778
hdl:20.500.11880/30909
http://dx.doi.org/10.22028/D291-33577
ISSN: 1932-6203
Date of registration: 17-Mar-2021
Description of the related object: Supporting Information
Related object: https://ndownloader.figstatic.com/files/25983787
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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