Please use this identifier to cite or link to this item:
doi:10.22028/D291-33577
Title: | IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations |
Author(s): | Vella, Giovanna Ritzmann, Felix Wolf, Lisa Kamyschnikov, Andreas Stodden, Hannah Herr, Christian Slevogt, Hortense Bals, Robert Beißwenger, Christoph |
Language: | English |
Title: | PLOS ONE |
Volume: | 16 |
Issue: | 1 |
Publisher/Platform: | Public Library of Science |
Year of Publication: | 2021 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Neutrophilic inflammation results in loss of lung function in chronic obstructive pulmonary disease (COPD). Gram-negative bacteria, such as nontypeable Haemophilus influenzae (NTHi), trigger acute exacerbations of COPD (AECOPD) and contribute to chronic lung inflammation. The pro-inflammatory cytokine interleukin-17C (IL-17C) is expressed by airway epithelial cells and regulates neutrophilic chemotaxis. Here, we explored the function of IL-17C in NTHi- and cigarette smoke (CS)-induced models of COPD. Neutrophilic inflammation and tissue destruction were decreased in lungs of IL-17C-deficient mice (Il-17c-/-) chronically exposed to NTHi. Numbers of pulmonary neutrophils were decreased in Il-17c-/- mice after acute exposure to the combination of NTHi and CS. However, Il-17c-/- mice were not protected from CS-induced lung inflammation. In a preliminary patient study, we show that IL-17C is present in sputum samples obtained during AECOPD and associates with disease severity. Concentrations of IL-17C were significantly increased during advanced COPD (GOLD III/IV) compared to moderate COPD (GOLD I/II). Concentrations of IL-17A and IL-17E did not associate with disease severity. Our data suggest that IL-17C promotes harmful pulmonary inflammation triggered by bacteria in COPD. |
DOI of the first publication: | 10.1371/journal.pone.0243484 |
Link to this record: | urn:nbn:de:bsz:291--ds-335778 hdl:20.500.11880/30909 http://dx.doi.org/10.22028/D291-33577 |
ISSN: | 1932-6203 |
Date of registration: | 17-Mar-2021 |
Description of the related object: | Supporting Information |
Related object: | https://ndownloader.figstatic.com/files/25983787 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Prof. Dr. Robert Bals |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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journal.pone.0243484.pdf | 2,45 MB | Adobe PDF | View/Open |
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