Please use this identifier to cite or link to this item:
doi:10.22028/D291-33015
Title: | Altered Ca2+ Homeostasis in Immune Cells during Aging: Role of Ion Channels |
Author(s): | Zöphel, Dorina Hof, Chantal Lis, Annette |
Language: | English |
Title: | International Journal of Molecular Sciences |
Volume: | 22 (2021) |
Issue: | 1 |
Publisher/Platform: | MDPI |
Year of Publication: | 2020 |
Free key words: | calcium homeostasis aging T cells T cell function calcium STIM Orai TRP channels potassium channels voltage-gated calcium channels purinergic receptors |
DDC notations: | 570 Life sciences, biology 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Aging is an unstoppable process and begins shortly after birth. Each cell of the organism is affected by the irreversible process, not only with equal density but also at varying ages and with different speed. Therefore, aging can also be understood as an adaptation to a continually changing cellular environment. One of these very prominent changes in age affects Ca2+ signaling. Especially immune cells highly rely on Ca2+-dependent processes and a strictly regulated Ca2+ homeostasis. The intricate patterns of impaired immune cell function may represent a deficit or compensatory mechanisms. Besides, altered immune function through Ca2+ signaling can profoundly affect the development of age-related disease. This review attempts to summarize changes in Ca2+ signaling due to channels and receptors in T cells and beyond in the context of aging. |
DOI of the first publication: | 10.3390/ijms22010110 |
Link to this record: | urn:nbn:de:bsz:291--ds-330151 hdl:20.500.11880/30492 http://dx.doi.org/10.22028/D291-33015 |
ISSN: | 1422-0067 |
Date of registration: | 29-Jan-2021 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Biophysik |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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ijms-22-00110.pdf | 1,32 MB | Adobe PDF | View/Open |
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