Please use this identifier to cite or link to this item: doi:10.22028/D291-32860
Title: Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells
Author(s): Janitschke, Daniel
Lauer, Anna A.
Bachmann, Cornel M.
Seyfried, Martin
Grimm, Heike S.
Hartmann, Tobias
Grimm, Marcus O. W.
Language: English
Title: International Journal of Molecular Sciences
Volume: 21
Issue: 23
Publisher/Platform: MDPI
Year of Publication: 2020
Free key words: methylxanthines
caffeine
theobromine
theophylline
pentoxifylline
propentofylline
oxidative stress
lipid homeostasis
energy metabolism
signal transduction
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceuticals. Here we investigate the transcriptional regulation of 83 genes linked to Alzheimer’s disease in the presence of five methylxanthines, including the most prominent naturally occurring methylxanthines—caffeine, theophylline and theobromine—and the synthetic methylxanthines pentoxifylline and propentofylline. Methylxanthine-regulated genes were found in pathways involved in processes including oxidative stress, lipid homeostasis, signal transduction, transcriptional regulation, as well as pathways involved in neuronal function. Interestingly, multivariate analysis revealed different or inverse effects on gene regulation for caffeine compared to the other methylxanthines, which was further substantiated by multiple comparison analysis, pointing out a distinct role for caffeine in gene regulation. Our results not only underline the beneficial effects of methylxanthines in the regulation of genes in neuroblastoma wild-type cells linked to neurodegenerative diseases in general, but also demonstrate that individual methylxanthines like caffeine mediate unique or inverse expression patterns. This suggests that the replacement of single methylxanthines by others could result in unexpected effects, which could not be anticipated by the comparison to other substances in this substance class.
DOI of the first publication: 10.3390/ijms21239015
Link to this record: urn:nbn:de:bsz:291--ds-328602
hdl:20.500.11880/30457
http://dx.doi.org/10.22028/D291-32860
ISSN: 1422-0067
Date of registration: 27-Jan-2021
Description of the related object: Supplementary Materials
Related object: http://www.mdpi.com/1422-0067/21/23/9015/s1
Faculty: M - Medizinische Fakultät
Department: M - Neurologie und Psychiatrie
Professorship: M - Prof. Dr. Tobias Hartmann
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
ijms-21-09015.pdf3,3 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons