Please use this identifier to cite or link to this item: doi:10.22028/D291-32565
Title: Scaffold-Mediated Gene Delivery for Osteochondral Repair
Author(s): Madry, Henning
Venkatesan, Jagadeesh Kumar
Carballo-Pedrares, Natalia
Rey-Rico, Ana
Cucchiarini, Magali
Language: English
Title: Pharmaceutics
Volume: 12
Issue: 10
Publisher/Platform: MDPI
Year of Publication: 2020
Free key words: osteochondral repair
gene therapy
tissue engineering
controlled delivery
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has recently emerged as an attractive therapeutic concept for osteochondral repair. The goal of this review is to provide an overview of the variety of biomaterials employed as nonviral or viral gene carriers for osteochondral repair approaches both in vitro and in vivo, including hydrogels, solid scaffolds, and hybrid materials. The data show that a site-specific delivery of therapeutic gene vectors in the context of acellular or cellular strategies allows for a spatial and temporal control of osteochondral neotissue composition in vitro. In vivo, implantation of acellular hydrogels loaded with nonviral or viral vectors has been reported to significantly improve osteochondral repair in translational defect models. These advances support the concept of scaffold-mediated gene delivery for osteochondral repair.
DOI of the first publication: 10.3390/pharmaceutics12100930
Link to this record: urn:nbn:de:bsz:291--ds-325652
hdl:20.500.11880/30454
http://dx.doi.org/10.22028/D291-32565
ISSN: 1999-4923
Date of registration: 26-Jan-2021
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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