Please use this identifier to cite or link to this item:
doi:10.22028/D291-32565
Title: | Scaffold-Mediated Gene Delivery for Osteochondral Repair |
Author(s): | Madry, Henning Venkatesan, Jagadeesh Kumar Carballo-Pedrares, Natalia Rey-Rico, Ana Cucchiarini, Magali |
Language: | English |
Title: | Pharmaceutics |
Volume: | 12 |
Issue: | 10 |
Publisher/Platform: | MDPI |
Year of Publication: | 2020 |
Free key words: | osteochondral repair gene therapy tissue engineering controlled delivery |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has recently emerged as an attractive therapeutic concept for osteochondral repair. The goal of this review is to provide an overview of the variety of biomaterials employed as nonviral or viral gene carriers for osteochondral repair approaches both in vitro and in vivo, including hydrogels, solid scaffolds, and hybrid materials. The data show that a site-specific delivery of therapeutic gene vectors in the context of acellular or cellular strategies allows for a spatial and temporal control of osteochondral neotissue composition in vitro. In vivo, implantation of acellular hydrogels loaded with nonviral or viral vectors has been reported to significantly improve osteochondral repair in translational defect models. These advances support the concept of scaffold-mediated gene delivery for osteochondral repair. |
DOI of the first publication: | 10.3390/pharmaceutics12100930 |
Link to this record: | urn:nbn:de:bsz:291--ds-325652 hdl:20.500.11880/30454 http://dx.doi.org/10.22028/D291-32565 |
ISSN: | 1999-4923 |
Date of registration: | 26-Jan-2021 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Orthopädie |
Professorship: | M - Prof. Dr. Henning Madry |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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pharmaceutics-12-00930-v2.pdf | 1,32 MB | Adobe PDF | View/Open |
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