Please use this identifier to cite or link to this item:
doi:10.22028/D291-30787
Title: | High prevalence of ESBL-producing Klebsiella pneumoniae in clinical samples from central Côte d'Ivoire |
Author(s): | Müller-Schulte, Eloise Tuo, Marie Nonfra Akoua-Koffi, Chantal Schaumburg, Frieder Becker, Sören L. |
Language: | English |
Title: | International Journal of Infectious Diseases |
Volume: | 91 |
Startpage: | 207 |
Endpage: | 209 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2019 |
Free key words: | Africa Antibiotics Antimicrobial resistance Bacteria Diagnosis Enterobacterales Sepsis |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Objectives: Infections caused by multidrug-resistant Enterobacterales pose a significant challenge to clinical patient care, particularly in resource-constrained settings where epidemiological data on antimicrobial resistance are scarce. The aim of this study was to determine the prevalence of extended spectrum beta-lactamase-(ESBL)-producing Klebsiella pneumoniae among clinical samples from a teaching hospital in Bouaké, central Côte d’Ivoire. Methods: Clinical specimens were collected from sterile and non-sterile body sites and were subjected to microbiological diagnostics (April 2016-June 2017). The antimicrobial susceptibility patterns of K. pneumoniae were analysed using automated resistance testing and double-disk diffusion to test for ESBL production. Multiplex PCR was carried out to determine the presence of the resistance-conferring genes blaCTX-M, blaSHV and blaTEM. Results: A total of 107 isolates were included, most of which were obtained from bloodstream (39%; n = 42) and urinary tract infections (39%; n = 42). Among all K. pneumoniae isolates, 84% (n = 90) were ESBL producers, many of which were also not susceptible to sulfonamides (99%), quinolones (81%) and aminoglycosides (79%). The majority of ESBL-producing strains harboured all three investigated bla genes. Conclusion: The high prevalence of ESBL-producing K. pneumoniae in clinical isolates from Côte d’Ivoire calls for revised empirical treatment regimens in critically ill patients with suspected Gram-negative infections, and the establishment of antimicrobial resistance surveillance systems. |
DOI of the first publication: | 10.1016/j.ijid.2019.11.024 |
Link to this record: | urn:nbn:de:bsz:291--ds-307879 hdl:20.500.11880/29052 http://dx.doi.org/10.22028/D291-30787 |
ISSN: | 12019712 |
Date of registration: | 24-Apr-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Infektionsmedizin |
Professorship: | M - Prof. Dr. Dr. Sören Becker |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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PIIS1201971219304643.pdf | High prevalence | 289,99 kB | Adobe PDF | View/Open |
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