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doi:10.22028/D291-34102
Titel: | Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations |
VerfasserIn: | Fortmann, Ingmar Dammann, Marie-Theres Humberg, Alexander Siller, Bastian Stichtenoth, Guido Engels, Geraldine Marißen, Janina Faust, Kirstin Hanke, Kathrin Goedicke-Fritz, Sybelle Derouet, Christoph Meyer, Sascha Stutz, Regine Kaiser, Elisabeth Herting, Egbert Göpel, Wolfgang Härtel, Christoph Zemlin, Michael on behalf of the German Neonatal Network (GNN) and the PRIMAL Consortium |
Sprache: | Englisch |
Titel: | Vaccines |
Bandnummer: | 9 |
Heft: | 5 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | immunization prematurity trained immunity long-term outcome |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | This study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associated long-term consequences. We performed an observational study of the GNN between 1st January 2010 and 31st December 2019. The immunization status for the hexavalent and pneumococcal immunization was evaluated in n = 8401 preterm infants <29 weeks of gestation. Univariate analysis and logistic/linear regression models were used to identify risk factors for vaccination delay and outcomes at a 5-year follow-up. In our cohort n = 824 (9.8%) ELGANs did not receive a timely first immunization with the hexavalent and pneumococcal vaccine. Risk factors for delayed vaccination were SGA status (18.1% vs. 13.5%; OR 1.3; 95% CI: 1.1–1.7), impaired growth and surrogates for complicated clinical courses (i.e., need for inotropes, necrotizing enterocolitis). At 5 years of age, timely immunized children had a lower risk of bronchitis (episodes within last year: 27.3% vs. 37.7%; OR 0.60, 95% CI: 0.42–0.86) but spirometry measures were unaffected. In conclusion, a significant proportion of ELGANs are untimely immunized, specifically those with increased vulnerability, even though they might particularly benefit from the immune-promoting effects of a timely vaccination. |
DOI der Erstveröffentlichung: | 10.3390/vaccines9050493 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-341028 hdl:20.500.11880/31359 http://dx.doi.org/10.22028/D291-34102 |
ISSN: | 2076-393X |
Datum des Eintrags: | 25-Mai-2021 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Materials |
In Beziehung stehendes Objekt: | https://www.mdpi.com/article/10.3390/vaccines9050493/s1 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Pädiatrie |
Professur: | M - Prof. Dr. Michael Zemlin |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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vaccines-09-00493-v2.pdf | 1,43 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons