Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-34102
Titel: Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations
VerfasserIn: Fortmann, Ingmar
Dammann, Marie-Theres
Humberg, Alexander
Siller, Bastian
Stichtenoth, Guido
Engels, Geraldine
Marißen, Janina
Faust, Kirstin
Hanke, Kathrin
Goedicke-Fritz, Sybelle
Derouet, Christoph
Meyer, Sascha
Stutz, Regine
Kaiser, Elisabeth
Herting, Egbert
Göpel, Wolfgang
Härtel, Christoph
Zemlin, Michael
on behalf of the German Neonatal Network (GNN) and the PRIMAL Consortium
Sprache: Englisch
Titel: Vaccines
Bandnummer: 9
Heft: 5
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: immunization
prematurity
trained immunity
long-term outcome
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: This study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associated long-term consequences. We performed an observational study of the GNN between 1st January 2010 and 31st December 2019. The immunization status for the hexavalent and pneumococcal immunization was evaluated in n = 8401 preterm infants <29 weeks of gestation. Univariate analysis and logistic/linear regression models were used to identify risk factors for vaccination delay and outcomes at a 5-year follow-up. In our cohort n = 824 (9.8%) ELGANs did not receive a timely first immunization with the hexavalent and pneumococcal vaccine. Risk factors for delayed vaccination were SGA status (18.1% vs. 13.5%; OR 1.3; 95% CI: 1.1–1.7), impaired growth and surrogates for complicated clinical courses (i.e., need for inotropes, necrotizing enterocolitis). At 5 years of age, timely immunized children had a lower risk of bronchitis (episodes within last year: 27.3% vs. 37.7%; OR 0.60, 95% CI: 0.42–0.86) but spirometry measures were unaffected. In conclusion, a significant proportion of ELGANs are untimely immunized, specifically those with increased vulnerability, even though they might particularly benefit from the immune-promoting effects of a timely vaccination.
DOI der Erstveröffentlichung: 10.3390/vaccines9050493
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-341028
hdl:20.500.11880/31359
http://dx.doi.org/10.22028/D291-34102
ISSN: 2076-393X
Datum des Eintrags: 25-Mai-2021
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/vaccines9050493/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Michael Zemlin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
vaccines-09-00493-v2.pdf1,43 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons