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Titel: Curcumin Nanocrystals: Production, Physicochemical Assessment, and In Vitro Evaluation of the Antimicrobial Effects against Bacterial Loading of the Implant Fixture
VerfasserIn: Negahdari, Ramin
Sharifi, Simin
Ghavimi, Mohammad Ali
Memar, Mohammad Yousef
Khaneshi, Bita
Maleki Dizaj, Solmaz
Eftekhari, Aziz
Cucchiarini, Magali
Sprache: Englisch
Titel: Applied Sciences
Bandnummer: 10
Heft: 23
Verlag/Plattform: MDPI
Erscheinungsjahr: 2020
Freie Schlagwörter: nanocurcumin
implant
antibacterial effects
peri-implantitis
removal rate
colonyforming unit
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Background: This study aimed to prepare and study physicochemical properties as well as the antibacterial action of curcumin nanocrystals inside the implant fixture against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Enterococcus faecalis (E. faecalis). Methods: Curcumin nanocrystals were prepared via precipitation combined with the spray drying method. The produced curcumin nanocrystals were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FTIR). Moreover, the in vitro antimicrobial effect of curcumin nanocrystals inside the implant fixture was assessed against E. coli, S. aureus, and E. faecalis. All implant-abutment assemblies were immersed in bacterial suspensions and were incubated at 24, 48, and 72 h. The contents of each implant were cultured to count the colony of bacteria at 37 ◦C for 24 h. Results: The prepared curcumin nanocrystals with a mean particle size of 95 nm and spherical morphology exhibited a removal rate of 99.99% for all bacteria. In addition, the colony-forming unit (CFU) of bacteria in exposure to nanocrystals significantly was reduced (p < 0.010) by increasing the time. Conclusions: Curcumin nanocrystals can be used inside the implant fixture as an antimicrobial agent in order to more stabilization of the implant.
DOI der Erstveröffentlichung: 10.3390/app10238356
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-328581
hdl:20.500.11880/30456
http://dx.doi.org/10.22028/D291-32858
ISSN: 2076-3417
Datum des Eintrags: 27-Jan-2021
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Orthopädie
Professur: M - Prof. Dr. Henning Madry
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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