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Titel: The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives
VerfasserIn: Eftekhari, Aziz
Maleki Dizaj, Solmaz
Sharifi, Simin
Salatin, Sara
Rahbar Saadat, Yalda
Zununi Vahed, Sepideh
Samiei, Mohammad
Ardalan, Mohammadreza
Rameshrad, Maryam
Ahmadian, Elham
Cucchiarini, Magali
Sprache: Englisch
Titel: International Journal of Molecular Sciences
Bandnummer: 21
Heft: 2
Verlag/Plattform: MDPI
Erscheinungsjahr: 2020
Freie Schlagwörter: nanomaterial
cartilage tissue engineering
regenerative medicine
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.
DOI der Erstveröffentlichung: 10.3390/ijms21020536
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-301709
hdl:20.500.11880/29285
http://dx.doi.org/10.22028/D291-30170
ISSN: 1422-0067
Datum des Eintrags: 18-Jun-2020
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Orthopädie
Professur: M - Prof. Dr. Henning Madry
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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