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Titel: STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment
VerfasserIn: Frisch, Janina
Angenendt, Adrian
Hoth, Markus
Prates Roma, Leticia
Lis, Annette
Sprache: Englisch
Titel: Cancers
Bandnummer: 11
Heft: 4
Verlag/Plattform: MDPI
Erscheinungsjahr: 2019
Freie Schlagwörter: Orai
STIM
calcium
reactive oxygen species
H2O
tumor microenvironment
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the extracellular matrix, soluble factors, and blood vessels. Interactions between the cells, matrix, soluble factors, and blood vessels generate this complex heterogeneous microenvironment. The TME may be metabolically beneficial or unbeneficial for tumor growth, it may favor or not favor a productive immune response against tumor cells, or it may even favor conditions suited to hijacking the immune system for benefitting tumor growth. Soluble factors relevant for TME include oxygen, reactive oxygen species (ROS), ATP, Ca2+, H+, growth factors, or cytokines. Ca2+ plays a prominent role in the TME because its concentration is directly linked to cancer cell proliferation, apoptosis, or migration but also to immune cell function. Stromal-interaction molecules (STIM)-activated Orai channels are major Ca2+ entry channels in cancer cells and immune cells, they are upregulated in many tumors, and they are strongly regulated by ROS. Thus, STIM and Orai are interesting candidates to regulate cancer cell fate in the TME. In this review, we summarize the current knowledge about the function of ROS and STIM/Orai in cancer cells; discuss their interdependencies; and propose new hypotheses how TME, ROS, and Orai channels influence each other.
DOI der Erstveröffentlichung: 10.3390/cancers11040457
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-279111
hdl:20.500.11880/28924
http://dx.doi.org/10.22028/D291-27911
ISSN: 2072-6694
Datum des Eintrags: 30-Mär-2020
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Biophysik
Professur: M - Prof. Dr. Markus Hoth
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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