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Titel: Active superelasticity in three-dimensional epithelia of controlled shape
VerfasserIn: Latorre, Ernest
Kale, Sohan
Casares, Laura
Gómez-González, Manuel
Uroz, Marina
Valon, Léo
Nair, Roshna V.
Garreta, Elena
Montserrat, Nuria
del Campo Bécares, Aránzazu
Ladoux, Benoit
Arroyo, Marino
Trepat, Xavier
Sprache: Englisch
Titel: Nature : the international journal of science
Bandnummer: 563
Heft: 7730
Startseite: 203
Endseite: 208
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2018
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Fundamental biological processes are carried out by curved epithelial sheets that enclose a pressurized lumen. How these sheets develop and withstand three-dimensional deformations has remained unclear. Here we combine measurements of epithelial tension and shape with theoretical modelling to show that epithelial sheets are active superelastic materials. We produce arrays of epithelial domes with controlled geometry. Quantification of luminal pressure and epithelial tension reveals a tensional plateau over several-fold areal strains. These extreme strains in the tissue are accommodated by highly heterogeneous strains at a cellular level, in seeming contradiction to the measured tensional uniformity. This phenomenon is reminiscent of superelasticity, a behaviour that is generally attributed to microscopic material instabilities in metal alloys. We show that in epithelial cells this instability is triggered by a stretch-induced dilution of the actin cortex, and is rescued by the intermediate filament network. Our study reveals a type of mechanical behaviour-which we term active superelasticity-that enables epithelial sheets to sustain extreme stretching under constant tension.
DOI der Erstveröffentlichung: 10.1038/s41586-018-0671-4
URL der Erstveröffentlichung: https://www.nature.com/articles/s41586-018-0671-4
Link zu diesem Datensatz: hdl:20.500.11880/28207
http://dx.doi.org/10.22028/D291-29494
ISSN: 1476-4687
0266-6561
0968-6797
Datum des Eintrags: 25-Okt-2019
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Chemie
Professur: NT - Prof. Dr. Aránzazu del Campo
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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