Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro

Abstract

To obtain more evidence for intracellular magnetic fluid hyperthermia (MFH), endocytosis and hyperthermia efficacy of silan and dextran magnetite was investigated. Differential endocytosis was observed in dependence of nanoparticle and cell type. Clonogenic survival was 3-fold lower after MFH versus waterbath hyperthermia. The selective 'remote inactivation' of cancer cells by an AC magnetic field has been demonstrated in vitro.